Glucose-responsive polyelectrolyte capsules

De Geest, Bruno G.;Jonas, Alain;Demeester, Joseph;De Smedt, Stefaan C.
(2006) Langmuir : the A C S journal of surfaces and colloids — Vol. 22, n° 11, p. 5070-5074 (2006)

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Authors
  • De Geest, Bruno G.
    Author
  • Jonas, Alainorcid-logoUCLouvain
    Author
  • Demeester, Joseph
    Author
  • De Smedt, Stefaan C.
    Author
Abstract
Phenylboronic acids are known to form covalent complexes with polyol compounds such as glucose. A novel polyelectrolyte, containing phenylboronic acid as a glucose-sensitive moiety, has been synthesized and used for the fabrication of glucose-sensitive hollow polyelectrolyte capsules using the layer-by-layer technique. The response to glucose was observed as a rather fast dissolution of the capsules when brought into contact with a glucose-containing medium. These polyelectrolyte capsules are the first polyelectrolyte capsules able to respond to a stimulus that can be provided by the human body ( i.e., an increase in glucose concentration). Therefore, the concept we present has promising applications in the biomedical field for the controlled delivery of insulin.
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De Geest, B. G., Jonas, A., Demeester, J., & De Smedt, S. C. (2006). Glucose-responsive polyelectrolyte capsules. Langmuir : the A C S journal of surfaces and colloids, 22(11), 5070-5074. https://doi.org/10.1021/la053368o (Original work published 2006)