Solvent-triggered breakdown of solid solution behaviour enables direct enantioselective crystallization of RS-phenprocoumon

Jiang, Yihua;Souare, Sokhna;Robeyns, Koen;Leng, Fucheng;Leyssens, Tom;et.al.
(2026) Chemical Communications — Vol. 62, n° 24, p. 6613-6616 (2026)

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Authors
  • Jiang, YihuaUCLouvain
    Author
  • Souare, SokhnaLaboratoire Sciences et Méthodes Séparatives, UMR 3233, Université Rouen Normandie, Normandie Université, 76000, Rouen, France
    Author
  • Robeyns, KoenUCLouvain
    Author
  • Leng, FuchengFood Science Building, University College Cork, College Road, Cork T12 K8AF, Ireland
    Author
  • Collard, LaurentUCLouvain
    Author
  • Leyssens, TomUCLouvain
    Author
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Abstract
We show that solvent selection plays a decisive role in chiral resolution of RS-phenprocoumon-quinidine. In particular, formation of a bis-acetone solvate suppresses solid solution formation, and affords spontaneous enantioselective crystallization of S-phenprocoumon with enantiomeric excesses of up to 92% in a single resolution step.
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Jiang, Y., Souare, S., Robeyns, K., Leng, F., Collard, L., & Leyssens, T. (2026). Solvent-triggered breakdown of solid solution behaviour enables direct enantioselective crystallization of RS-phenprocoumon. Chemical Communications, 62(24), 6613-6616. https://doi.org/10.1039/D6CC00933F (Original work published 2026)