Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells
(2010) Cancer Genome and Tumor Microenvironment — ISBN: [978-1-4419-0710-3], p. 33-66, published
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- Abstract
- As described in the previous chapter, the loss of E-cadherin is the key event in epithelial–mesenchymal transition. While downregulation of E-cadherin could occur via aberrant Akt signaling, direct somatic mutations in E-cadherin are frequent in epithelial tumors such as diffuse-type gastric and lobular breast cancers, where they can be found in up to 50% of primary neoplasms (Berx et al. 1998). E-cadherin mutations were also observed in primary endometrial and ovarian carcinomas, albeit with a lower frequency (Risinger et al. 1994; Muta et al. 1996). The consequences of these mutations for EMT and tumor cell invasion are discussed below.
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Citations
Lien, W.-H., & Vasioukhin, V. (2010). Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells. In Andrei Thomas-Tikhonenko (ed.), Cancer Genome and Tumor Microenvironment (p. p. 33-66). Springer. https://doi.org/10.1007/978-1-4419-0711-0_3