Regional Localization of the Human Glutaminase (gls) and Interleukin-9 (il9) Genes By Insitu Hybridization
(1991) 2ND INTERNATIONAL WORKSHOP ON HUMAN CHROMOSOME 17 — Location: PARK CITY(Ut) (15.March.1991)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- Phosphate-activated glutaminase is found in mammalian small intestine, brain, and kidney, but not in liver. The enzyme initiates the catabolism of glutamine as the principal respiratory fuel in the small intestine, may synthesize the neurotransmitter glutamate in the brain, and functions in the kidney to help maintain systemic pH homeostasis. Interleukin-9 (IL9) is a relatively new cytokine that supports the growth of helper T-cell clones, mast cells, and megakaryoblastic leukemia cells. cDNA clones have recently been obtained for each of these genes. The human loci for phosphate-activated glutaminase (GLS) and IL9 have previously been mapped to chromosomes 2 and 5, respectively, by analysis of somatic cell hybrid DNAs. By using chromosomal in situ hybridization, we have regionally mapped GLS to 2q32 --> q34 and IL9 to 5q31 --> q35.
- Affiliations
Citations
Modi, WS., Pollock, DD., Mock, BA., Banner, C., Renauld, J.-C., & Van Snick, J. (1991). Regional Localization of the Human Glutaminase (gls) and Interleukin-9 (il9) Genes By Insitu Hybridization. Cytogenetics and Cell Genetics, 57(2-3), 114-116. https://doi.org/10.1159/000133126 (Original work published 1991)