Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials.
The improved immune response to PhtD vaccine containing the AS02V adjuvant system in comparison to alum suggests that the reduced immune response to vaccines in older adults can be partially restored to the response level observed in young adults. ClinicalTrials.gov identifiers: NCT00307528/NCT01767402.
Leroux-Roels, I., Devaster, J.-M., Leroux-Roels, G., Verlant, V., Henckaerts, I., Moris, P., Hermand, P., Van Belle, P., Poolman, J. T., Vandepapelière, P., & Horsmans, Y. (2013). Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials. Vaccine, in press(in press), in press. https://doi.org/10.1016/j.vaccine.2013.10.052 (Original work published 2013)