Oligonucleotides with cyclohexene-nucleoside building blocks: Crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC

Robeyns, Koen;Herdewijn, P.;Van Meervelt, L.
(2005) Acta Crystallographica Section F: Structural Biology and Crystallization Communications — Vol. 61, n° 6, p. 585-586 (2005)

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  • Robeyns, KoenUCLouvain
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  • Herdewijn, P.
    Author
  • Van Meervelt, L.
    Author
Abstract
Cyclohexene nucleic acids contain a cyclohexene ring instead of the normal β-D-2′-deoxyribose. The cyclohexene oligonucleotide GTGTACAC was synthesized using phosphoramidite chemistry and standard protecting groups. Crystals of GTGTACAC were obtained at 289 K by the hanging-drop vapour-diffusion technique. The crystals diffract to 1.7 Å resolution and belong to the trigonal space group R3, with unit-cell parameters a = 41.434, c = 66.735 Å. © 2005 International Union of Crystallography. All rights reserved.
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  • KU LEUVENDepartment of Chemistry

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Robeyns, K., Herdewijn, P., & Van Meervelt, L. (2005). Oligonucleotides with cyclohexene-nucleoside building blocks: Crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 61(6), 585-586. https://doi.org/10.1107/S1744309105015228 (Original work published 2005)