Major cytochrome P-450 families: implications in health and liver diseases
(1997) Acta Gastro-Enterologica Belgica — Vol. 60, n° 1, p. 2-10 (2021)
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- Abstract
- Cytochromes P-450 are a superfamily of hemoproteins which represent the main pathway for drug and chemical oxidation. This superfamily is divided into families, subfamilies and/or single enzymes. The majority of P-450s involved in drug metabolism appear to belong to three distinct families termed CYP1, CYP2 and CYP3. Numerous invasive and non-invasive methodologies have been developed to study these enzymes. Their activities are modulated by genetic and nongenetic factors as well as pathological conditions. In this work, the significance of genetic and nongenetic control of P-450s activities in normal subjects is described. Thereafter, the impact of P-450s on the apparition of liver diseases and the effects of liver disease on P-450s activities is emphasized. In conclusion, future perspectives on this field are presented.
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Horsmans, Y. (1997). Major cytochrome P-450 families: implications in health and liver diseases. Acta Gastro-Enterologica Belgica, 60(1), 2-10. https://hdl.handle.net/2078.5/166352 (Original work published 2021)