Comorbidities and overlap syndromes in functional dyspepsia
(2023)
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- Abstract
- Functional dyspepsia is a functional disorder of the upper digestive tract manifested by indigestion and pain in the stomach region. Delayed emptying of the stomach and hypersensitivity to gastric distension are found in some patients. Comorbidities or overlap syndromes are frequently found in the disorder: organic diseases, psychological problems (sleep disorders, etc.) and other functional disorders, digestive (irritable bowel syndrome, chronic nausea and vomiting syndrome, etc.) or not (bladder pain syndrome). After synthesising current knowledge in this field, we assessed different comorbidities and their impact on this disorder, and explored the mechanisms involved in these associations. We have shown that comorbidities are frequent and that an overlap syndrome is associated with more severe digestive symptoms, greater psychological distress and poorer quality of life in this disorder. An association with bladder pain syndrome is first described. Dyspeptic symptoms are influenced by the emptying of the stomach only in patients with severely delayed emptying but not in others. Finally, an animal model has been developed in the rat: inflammation of the colon induced by a chemical substance leads to hypersensitivity of the stomach; this cross-sensitisation is mediated by microglia, cells present in the central nervous system, and is prevented by the administration of minocycline, an inhibitor of these cells.
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Wuestenberghs, F. (2023). Comorbidities and overlap syndromes in functional dyspepsia. https://hdl.handle.net/2078.5/243378