Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient
(2005) Gynecologic Oncology — Vol. 98, n° 2, p. 329-331 (2005)
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- BACKGROUND: Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia. CASE: A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. The diagnosis work-up revealed that she suffered from osteomalacia due to a chemotherapy-induced Fanconi syndrome. The patient recovered completely with oral calcitriol supplements. CONCLUSIONS: This very rare chemotherapy-complication suggests that detection of potential tubular dysfunction, by regular serum electrolyte monitoring of patients receiving ifosfamide, may be a reasonable approach to diagnose early chemotherapy-induced Fanconi syndrome, even in adults.
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Citations
Duck, L., Devogelaer, J.-P., Persu, A., Berlière, M., Caussin, E., Baurain, J.-F., & Machiels, J.-P. (2005). Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient. Gynecologic Oncology, 98(2), 329-331. https://doi.org/10.1016/j.ygyno.2005.05.014 (Original work published 2005)