Synthesis, crystal structures and biological evaluation of new pyridazine derivatives
(2020) Journal of Molecular Structure — Vol. 1200 (2020)
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- Authors
Gupta, Deepak 
- Abstract
- A series of functionalized pyridazine derivatives (1–10) 4-phenyl-3,6-di(pyridine-4-yl)pyridazine (1), 3-(3,6-di(pyridin-4-yl)pyridazin-4-yl)aniline (2), 4-(pyridin-3-yl)-3,6-di(pyridin-4-yl)pyridazine (3), 3,6-di(pyridin-4-yl)-4-(thiophen-2-yl)pyridazine (4), 6-methyl-1,4-di(pyridin-4-yl)-5H-pyrrolo[3,4-d]pyridazine-5,7(6H)-dione (5), 4-phenyl-3,6-di(pyridine-3-yl)pyridazine (6), 3-(3,6-di(pyridin-4-yl)pyridazin-3-yl)aniline (7), 3,4,6-tri(pyridin-3-yl)pyridazine (8), 3,6-di(pyridin-3-yl)-4-(thiophen-2-yl)pyridazine (9), 6-methyl-1,4-di(pyridin-3-yl)-5H-pyrrolo[3,4-d]pyridazine-5,7(6H)-dione (10) were synthesized by one-step methodologies which also include Inverse Electron Demand Diels-Alder reaction. The compounds were isolated in high yields without any tedious purification procedures and characterized by NMR, Mass spectrometry, Elemental Analysis and X-ray diffraction techniques. The crystal structures of five compounds were studied. The pyridazines were subjected to anti-microbial evaluations where few of the compounds showed moderate to high activity against most of the bacteria and fungi presented in this study.
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Citations
Singh, B., Bhatia, R., Pani, B., & Gupta, D. (2020). Synthesis, crystal structures and biological evaluation of new pyridazine derivatives. Journal of Molecular Structure, 1200. https://doi.org/10.1016/j.molstruc.2019.127084 (Original work published 2020)