Scalable and sustainable mechanochemical deracemisation by resonant acoustic mixing

Wery, Guillaume;Gieling, Job;El Kaderi, Zoer;Hendrickx, Leeroy;Baier, Daniel M;et.al.
(2026) Green Chemistry — (2026)

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Authors
  • Wery, GuillaumeUCLouvain
    Author
  • Gieling, JobUCLouvain
    Author
  • El Kaderi, ZoerDepartment of Molecular Chemistry, Materials and Catalysis; Institute of Condensed Matter and Nanosciences; Université Catholique de Louvain, Place Louis Pasteur, 1 bte L4.01.06, 1348 Louvain-La-Neuve, Belgium
    Author
  • Hendrickx, LeeroyMax Planck Institute for Chemical Energy Conversion, Stiftstrasse, 34-36, 45470 Mülheim an der Ruhr, Germany
    Author
  • Leyssens, TomUCLouvain
    Author
  • Baier, Daniel Morcid-logoDepartment of Molecular Chemistry, Materials and Catalysis; Institute of Condensed Matter and Nanosciences; Université Catholique de Louvain, Place Louis Pasteur, 1 bte L4.01.06, 1348 Louvain-La-Neuve, Belgium
    Author
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Abstract
Resonant Acoustic Mixing (RAM) is introduced as a solvent-minimised, scalable approach to deracemisation, achieving enantiomeric excesses of up to 91%. The influence of processing parameters such as amount and nature of liquid additive on the deracemisation outcome were systematically investigated. RAM furthermore shows 5-fold upscaling ability, facilitating near-gram-scale deracemisation with minimal solvent use (η = 0.02) and reduced reaction times without the need for milling media. Notably, a racemic mixture was deracemised to 73% ee in 1.5 hours, showing enhanced efficiency compared to ball-milling and solvent-based deracemisation approaches. Mechanochemical deracemisation by RAM is a significant advancement, offering a faster, waste-minimising and scalable method, enabling a pathway to large-scale deracemisation processes while reducing waste.
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Wery, G., Gieling, J., El Kaderi, Z., Hendrickx, L., Wiegand, T., Bolm, C., Leyssens, T., & Baier, D. M. (2026). Scalable and sustainable mechanochemical deracemisation by resonant acoustic mixing. Green Chemistry. Published. https://doi.org/10.1039/D5GC06927K (Original work published 2026)