Identification of an inward Na+ current activated by acetylcholine in mouse pancreatic -cells

Rolland, Jean-François;Henquin, Jean-Claude;Gilon, Patrick
(2001) 37th Annual Meeting of the EASD — Location: (United Kingdom) Glasgow (9.September.2001)

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Authors
  • Rolland, Jean-FrançoisUCLouvain
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  • Henquin, Jean-ClaudeUCLouvain
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  • Gilon, Patrickorcid-logoUCLouvain
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Abstract
Our aim was to identify and characterize the current by which acetylcholine (ACh) depolarizes the plasma membrane of pancreatic beta-cells. The observations that this depolarization is abrogated by omission of Na+, and that ACh increases cytosolic [Na+] suggested that the current is carried by Na+. [...]
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Rolland, J.-F., Henquin, J.-C., & Gilon, P. (2001). Identification of an inward Na+ current activated by acetylcholine in mouse pancreatic -cells. Diabetologia : clinical and experimental diabetes and metabolism, 44(Suppl 1), A132. https://hdl.handle.net/2078.5/119025 (Original work published 2001)