Natural killer cell activation after infection with lactate dehydrogenase-elevating virus.
(2002) Journal of General Virology — Vol. 83, n° Pt 11, p. 2709-2716 (2002)
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- Authors
Coutelier, Jean-Paul 
- Abstract
- Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-gamma), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced IFN-gamma message expression and cytolysis, was observed. LDV triggered a large increase in serum IFN-gamma levels. Because NK cells and IFN-gamma may participate in the defence against virus infection, we analysed their possible role in the control of LDV titres with a new agglutination assay. Our results indicate that neither the activation of NK cells nor the IFN-gamma secretion affect the early and rapid virus replication that follows LDV inoculation.
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Citations
Markine-Goriaynoff, D., Hulhoven, X., Cambiaso, C., Monteyne, P., Briet, T., Gonzalez, M.-D., Coulie, P., & Coutelier, J.-P. (2002). Natural killer cell activation after infection with lactate dehydrogenase-elevating virus. Journal of General Virology, 83(Pt 11), 2709-2716. https://doi.org/10.1099/0022-1317-83-11-2709 (Original work published 2002)