Vinylsiloxanes as Alkenylating Agents in Nickel-Catalyzed Difunctionalization of Vinylarenes

Salamone, Logan;Tan, Qihang;Evano, Gwilherm;Riant, Olivier
(2026) Organic Letters — Vol. 28, n° 17, p. 5592-5597 (2026)

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Authors
  • Salamone, LoganUCLouvain
    Author
  • Tan, QihangInstitute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1 bte L4.01.02, 1348 Louvain-la-Neuve, Belgium
    Author
  • Evano, Gwilhermorcid-logoLaboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium
    Author
  • Riant, OlivierUCLouvain
    Author
Abstract
We report the first directing-group-free nickel-catalyzed difunctionalization of vinylarenes using bench-stable vinylsiloxanes as alkenylating agents. This mild, scalable and stereospecific method provides regioselective access to functionalized disubstituted alkenes with broad scope, low catalyst loadings, and minimal Z-isomerization, establishing vinylsiloxanes as versatile alkenyl transfer partners in multicomponent nickel catalysis.
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Salamone, L., Tan, Q., Evano, G., & Riant, O. (2026). Vinylsiloxanes as Alkenylating Agents in Nickel-Catalyzed Difunctionalization of Vinylarenes. Organic Letters, 28(17), 5592-5597. https://doi.org/10.1021/acs.orglett.6c01252 (Original work published 2026)