Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities

Kundu, NG;Das, P.;Balzarini, Jan;De Clercq, Etienne
(1997) Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 5, n° 11, p. 2011-2018 (1997)

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  • Kundu, NG
    Author
  • Das, P.
    Author
  • Balzarini, JanKUL
    Author
  • De Clercq, EtienneUCLouvain
    Author
Abstract
[E]-6-(2-Acylvinyl)uracils and their corresponding 1-(2-hydroxyethoxy)methyl derivatives were synthesized through palladium-catalyzed reactions which involved an interesting rearrangement. Some of the acylvinyl uracils (3, 4, and 5) and the acyclonucleosides (8 and 10) showed pronounced activity against human T-lymphocyte Molt 4/C8 and CEM cells. However, they were less toxic to murine L1210 and FM3A cells. The compounds did not have any marked antiviral activity. (C) 1997 Elsevier Science Ltd.
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Kundu, N., Das, P., Balzarini, J., & De Clercq, E. (1997). Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities. Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, 5(11), 2011-2018. https://hdl.handle.net/2078.5/91764 (Original work published 1997)