Homeostasis of taurine and glutamate plasma levels after acute and chronic ethanol administration in man
(1999) Neuroscience Research Communications — Vol. 24, n° 1, p. 41-49 (1999)
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- Abstract
- Taurine homeostasis is perturbed after acute and chronic ethanol administration. An oral dose of ethanol, (0.8 g / kg) significantly decreased the plasma taurine content 90 minutes after its administration, while glutamic acid content increased significantly at 30 minutes. Chronic alcohol abusers, showed significant increases in plasma taurine content 7 days after alcohol withdrawal. In 50% of these patients the taurine levels exceeding the reference range and correlated with the elevated levels of plasma glutamic acid. In addition in these patients there was also a significant decrease in anxiety score, CIWA Ar, (p<0.01). Although the correlation between taurine and glutamate has been described in other diseases this is the first time that such changes have been reported after acute or chronic ethanol administration.
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Ward, R. J., Marshall, E., Ball, D., Martinez, J., & De Witte, P. (1999). Homeostasis of taurine and glutamate plasma levels after acute and chronic ethanol administration in man. Neuroscience Research Communications, 24(1), 41-49. https://doi.org/10.1002/(SICI)1520-6769(199901/02)24:1<41::AID-NRC6>3.0.CO;2-8 (Original work published 1999)