Evaluation of tumor hemodynamics by magnetic resonance imaging : consequence of a modulation of perfusion on chemotherapy delivery
(2014)
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- Authors
- Supervisors
- Gallez, Bernard
- Abstract
- An under-estimated source of anticancer drug resistance is the impaired drug delivery of chemotherapeutic agents to solid tumors. One of the barriers to drug delivery is the abnormal structure of tumor blood vessels leading, among other consequences, to spatial and temporal heterogeneities in tumor blood flow. A potential way to improve chemotherapy efficacy is to use co-treatments which could improve the uptake and penetration of chemotherapy into the tumor. In this context, this thesis investigates how a modulation of tumor blood flow could impact the delivery of chemotherapeutic agents, using magnetic resonance imaging techniques. The value of MR imaging biomarkers to predict and monitor chemotherapy delivery is also explored. Such biomarkers could be helpful for assessment of new drugs and therapeutic management of patients.
- Affiliations
UCLouvain SSS/LDRI - Louvain Drug Research Institute
Citations
Fruytier, A.-C. (2014). Evaluation of tumor hemodynamics by magnetic resonance imaging : consequence of a modulation of perfusion on chemotherapy delivery. https://hdl.handle.net/2078.5/194645