Identification of the new allele B*3556 and extension of the sequences of B*4420 and B*4427
(2006) Tissue Antigens : immune response genetics — Vol. 68, n° 3, p. 253-256 (2006)
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- Abstract
- A new B*35 allele, B*3556, was identified in a Caucasian individual. Direct sequencing of exons 2 and 3 revealed that B*3556 was identical to B*3503, except for a nucleotide substitution from G to A at position 302, which causes a change from AGC to AAC at codon 101. This results in an amino acid change from Ser to Asn at position 77 of the mature protein. Two B*44 alleles, B*4420 and B*4427, were detected in a liver recipient and in an unrelated bone marrow donor, respectively, and their sequences were confirmed. The sequences of exons 1,4 and 5 were also elucidated; for B*4420, these exons proved to be identical to those of B*440201. The sequence of exon 5 of B*4427 showed three mismatches with that of B*440201, implicating that it probably arose from B*440201 by allele conversion with an allele of the B*15, 45, 46, 49 or 50 allele group. Elucidation of the sequence of introns 3 and 4 indicated that the breakpoint for allele conversion has to be located in intron 3 or exon 4.
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Voorter, C. E. M., Latinne, D., Gervais, T., Mulkers, E. M. T., & van den Berg-Loonen, E. M. (2006). Identification of the new allele B*3556 and extension of the sequences of B*4420 and B*4427. Tissue Antigens : immune response genetics, 68(3), 253-256. https://doi.org/10.1111/j.1399-0039.2006.00654.x (Original work published 2006)