Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology.
(2012) Fertility and sterility — Vol. 98, n° 3, p. 520-528 (2012)
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- Abstract
- Nuclear factor-kappaB activation dysregulation in the endometrium of endometriosis patients may explain some endometrial biological alterations associated with endometriosis. The scientific evidence strongly suggests that NF-κB activity in endometriotic cells stimulates inflammation and cell proliferation and inhibits apoptosis, favoring the development and maintenance of endometriosis. Iron overload in the pelvic cavity of endometriosis patients could be a main factor enhancing oxidative stress and activating NF-κB in a chronic manner, contributing to endometriosis establishment and growth.
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González Ramos, R., Defrere, S., & Devoto, L. (2012). Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertility and sterility, 98(3), 520-528. https://doi.org/10.1016/j.fertnstert.2012.06.021 (Original work published 2012)