Force Generation: ATP-Powered Proteasomes Pull the Rope

Dufrêne, Yves;Müller, Daniel J.
(2011) Current Biology — Vol. 21, n° 11, p. R427-R430 (2011)

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Abstract
Recently, single-molecule force spectroscopy techniques have provided unprecedented opportunities to apply and to quantify forces that guide protein (un-)folding. A new study provides fascinating insights into the sophisticated mechanism by which an ATP-fueled proteolytic machine generates mechanical forces to unfold and translocate multidomain substrates.
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Dufrêne, Y., & Müller, D. J. (2011). Force Generation: ATP-Powered Proteasomes Pull the Rope. Current Biology, 21(11), R427-R430. https://doi.org/10.1016/j.cub.2011.04.046 (Original work published 2011)