A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma.

Gaugler, Béatrice;Brouwenstijn, Nathalie;Vantomme, Valérie;Szikora, Jean-Pierre;Van den Eynde, Benoit;et.al.
(1996) Immunogenetics — Vol. 44, n° 5, p. 323-330 (1996)

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Authors
  • Gaugler, BéatriceUCLouvain
    Author
  • Brouwenstijn, NathalieDept. of Clinical Oncology, Academic Hospital Leiden, P. O. Box 9600, 2300 RC Leiden, The Netherlands
    Author
  • Vantomme, ValérieUCLouvain
    Author
  • Szikora, Jean-Pierreorcid-logoUCLouvain
    Author
  • Patard, Jean-JacquesUCLouvain
    Author
  • Boon, ThierryUCLouvain
    Author
  • Van den Eynde, Benoitorcid-logoUCLouvain
    Author
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Abstract
Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.
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Gaugler, B., Brouwenstijn, N., Vantomme, V., Szikora, J.-P., Van der Spek, C. W., Patard, J.-J., Boon, T., Schrier, P., & Van den Eynde, B. (1996). A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. Immunogenetics, 44(5), 323-330. https://doi.org/10.1007/BF02602776 (Original work published 1996)