Hematopoietic growth factors as supportive therapy for cancer- and chemotherapy-induced conditions.
(1991) Current Opinion in Oncology — Vol. 3, n° 4, p. 648-655 (1991)
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- Abstract
- A number of human hematopoietic growth factors have been genetically cloned and recombinant proteins produced. Several phase I and II clinical trials have already been published and results from phase III studies are becoming available. The use of erythropoietin to alleviate chemotherapy-induced myelosuppression is being tested. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have been extensively studied in patients receiving chemotherapy at standard or escalated doses and after bone marrow transplantation and appear to ameliorate chemotherapy-induced neutropenia and to speed bone marrow engraftment after high-dose cancer therapy. Interleukin-3 and interleukin-6 are quite early in their clinical development, but appear able to alleviate post-chemotherapy thrombocytopenia.
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Symann, M. (1991). Hematopoietic growth factors as supportive therapy for cancer- and chemotherapy-induced conditions. Current Opinion in Oncology, 3(4), 648-655. https://hdl.handle.net/2078.5/135161 (Original work published 1991)