A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

Ichimura, Atsuhiko;Matsumoto, Sachiko;Suzuki, Shinobu;Dan, Takashi;Miyata, Toshio;et.al.
(2013) Arteriosclerosis, Thrombosis, and Vascular Biology — Vol. 33, n° 5, p. 935-942 (2013)

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Authors
  • Ichimura, Atsuhiko
    Author
  • Matsumoto, Sachiko
    Author
  • Suzuki, Shinobu
    Author
  • Dan, Takashi
    Author
  • Van Ypersele de Strihou, CharlesUCLouvain
    Author
  • Miyata, Toshio
    Author
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Abstract
These findings suggest that a small molecule PAI-1 inhibitor represents a novel class of anti-inflammatory agents targeting Mϕ migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor-related protein.
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Ichimura, A., Matsumoto, S., Suzuki, S., Dan, T., Yamaki, S., Sato, Y., Kiyomoto, H., Ishii, N., Okada, K., Matsuo, O., Hou, F.-F., Vaughan, D. E., Van Ypersele de Strihou, C., & Miyata, T. (2013). A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(5), 935-942. https://doi.org/10.1161/ATVBAHA.113.301224 (Original work published 2013)