[Auto-vaccines: an immunological alternative to gene silencing].
(2013) M/S : médecine sciences — Vol. 29, n° 4, p. 425-429 (2013)
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- Abstract
- Auto-vaccination is a procedure that recently attracted the interest of a growing number of investigators as an alternative to gene inactivation for functional studies of cytokines or other mediators. It is based on the observation that autologous cytokines cross-linked to a foreign protein or peptide are recognized by self-reactive B cells that present foreign peptides, and by doing so attract illicit help from helper T cells that recognize the foreign peptide on the self-reactive B cell MHC Class II complex. This leads to the production of antibodies reacting with self-proteins and thus to neutralization of the targeted factor. Here, we summarize the different techniques that were successful in breaking this self-tolerance and provide several examples of the functional consequences of these auto-vaccines. An additional output of auto-vaccination is the production of mouse monoclonal antibodies against mouse factors. Such antibodies have obvious advantages for long-term use in vivo.
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Uyttenhove, C., & Van Snick, J. (2013). [Auto-vaccines: an immunological alternative to gene silencing]. M/S : médecine sciences, 29(4), 425-429. https://doi.org/10.1051/medsci/2013294017 (Original work published 2013)