Effects of maternal protein malnutrition on fetal growth, plasma insulin-like growth factors, insulin-like growth factor binding proteins, and liver insulin-like growth factor gene expression in the rat.

Muaku, S M;Beauloye, Véronique;Thissen, Jean-Paul;Underwood, L E;Maiter, Dominique;et.al.
(1995) Pediatric Research : international journal of human developmental biology — Vol. 37, n° 3, p. 334-342 (1995)

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  • Muaku, S M
    Author
  • Beauloye, VéroniqueUCLouvain
    Author
  • Thissen, Jean-Paulorcid-logoUCLouvain
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  • Underwood, L E
    Author
  • Ketelslegers, Jean-MarieUCLouvain
    Author
  • Maiter, DominiqueUCLouvain
    Author
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Abstract
We examined the effects of maternal dietary protein restriction on fetal growth and expression of IGF-I and -II, and IGF-binding proteins (IGFBP). We sought to dissociate the respective effects of maternal protein versus calorie restriction on growth indices and IGF synthesis by the neonates of protein-restricted dams. Pregnant Wistar rats (six to eight per group) fed a low (5%) protein diet throughout gestation had impaired body weight gain compared with controls fed a normal (20%) protein diet (by 45%, p < 0.001). Their serum and liver IGF-I concentrations and liver IGF-I mRNA concentrations were also reduced by 60, 80, and 50%, respectively. Serum IGFBP-3 was reduced by 60% in protein-restricted dams within 1 to 2 h after delivery (p < 0.001 versus controls), although IGFBP-1, -2, and -4 were not significantly affected by the dietary protein intake. In pups of protein-restricted dams, the mean body and liver weight at birth was 15-20% less than that observed in the progeny from normal protein-fed dams (p < 0.01). Their plasma and liver IGF-I concentrations were 30 and 60% lower, respectively, whereas liver IGF-I mRNA abundance was reduced by 50% (p < 0.01). In contrast, neonatal plasma IGF-II and liver IGF-II mRNA concentrations were not significantly affected by the maternal protein malnutrition. Also, the plasma levels of IGFBP were not altered in the growth-retarded pups. Maternal protein restriction did not affect fetal and placental growth, plasma and liver IGF-I levels, and liver IGF-I mRNA abundance in 20-d-old fetuses.(ABSTRACT TRUNCATED AT 250 WORDS)
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Muaku, S. M., Beauloye, V., Thissen, J.-P., Underwood, L. E., Ketelslegers, J.-M., & Maiter, D. (1995). Effects of maternal protein malnutrition on fetal growth, plasma insulin-like growth factors, insulin-like growth factor binding proteins, and liver insulin-like growth factor gene expression in the rat. Pediatric Research : international journal of human developmental biology, 37(3), 334-342. https://doi.org/10.1203/00006450-199503000-00014 (Original work published 1995)