Fragrance allergy: assessing the safety of washed fabrics
(2010) Contact Dermatitis : environmental and occupational dermatitis — Vol. 62, n° 6, p. 349-354 (2010)
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- Background: Previously, a quantitative risk assessment suggested there was no risk of induction of fragrance allergy from minor residues of fragrance chemicals on washed fabrics. Objective: To investigate whether there was any risk of the elicitation of contact allergy from fragrance chemical residues on fabric in individuals who were already sensitized. Methods: Thirty-six subjects with a positive patch test to isoeugenol (n = 19) or hydroxyisohexyl 3-cyclohexene carboxaldehyde (n = 17) were recruited. Dose-response and fabric patch tests were performed, respectively, with filter paper and a cotton sample loaded with fragrance in ethanol-diethylphthalate (DEP) and applied in a Finn Chamber (R) or a Hill Top Chamber (R). Results: Only two subjects reacted to an isoeugenol patch test concentration of 0.01% (>20x the estimated likely skin exposure level), none reacted to lower concentrations. Of 36 subjects, 18 reacted to the fabric patch treated with ethanol-DEP vehicle alone and 20 to the fragrance-chemical-treated fabric patch. These were only minor non-specific skin reactions. They were also quite evenly distributed between the two fragrance chemical allergic groups. Conclusions: On the basis of the examples studied, fragrance chemical residues present on fabric do not appear to present a risk of the elicitation of immediate or delayed allergic skin reactions on individuals already sensitized.
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Basketter, D. A., Pons-Guiraud, A., van Asten, A., Laverdet, C., Marty, J.-P., Martin, L., Berthod, D., Siest, S., Giordano-Labadie, F., Tennstedt, D., Baeck, M., Vigan, M., Laine, G., Le Coz, C. J., Jacobs, M.-C., Bayrou, O., & Germaux, M.-A. (2010). Fragrance allergy: assessing the safety of washed fabrics. Contact Dermatitis : environmental and occupational dermatitis, 62(6), 349-354. https://doi.org/10.1111/j.1600-0536.2010.01728.x (Original work published 2010)