Identification of the nuclear transcription factor NF kappa B in rat brain after in vivo ethanol administration
(1996) FEBS Letters — Vol. 389, n° 2, p. 119-122 (1996)
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- Abstract
- NF kappa B, a nuclear transcription factor, was induced in the brain nuclear fraction of naive rats after an acute injection of ethanol, 2 g/kg. In contrast, rats which had been chronically alcoholised showed the constitutively active NF kappa B-like complex only after a further acute dose of ethanol. Hepatic nuclear fractions did not exhibit the specific NF kappa B-like complex during the first 45 min after acute ethanol injection, beyond that which was normally constitutively present, Such activation of NF kappa B-like complex in the brains of the naive rats may play an important role in the cellular protective response.
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Ward, R. J., Zhang, Y., Crichton, R., Piret, B., Piette, J., & De Witte, P. (1996). Identification of the nuclear transcription factor NF kappa B in rat brain after in vivo ethanol administration. FEBS Letters, 389(2), 119-122. https://doi.org/10.1016/0014-5793(96)00545-5 (Original work published 1996)