Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes.
(1993) Drug metabolism and disposition: the biological fate of chemicals — Vol. 21, n° 5, p. 850-854 (1993)
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- Abstract
- A novel metabolite of FK-506-a C13, C15, C31 O-demethyl C19 hydroxymethyl C36 isomerized epoxide of FK-506 obtained from erythromycin-induced rabbit liver microsomes--was isolated by HPLC and identified by FAB/MS and NMR. The existence of ring-chain tautomers for this metabolite is demonstrated by NMR spectroscopy. FAB/MS, and HPLC.
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Lhoëst, G., Verbeeck, R. K., & Maton, N. (1993). Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 21(5), 850-854. https://hdl.handle.net/2078.5/70182 (Original work published 1993)