Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs.
(1999) Pharmaceutical Research — Vol. 16, n° 4, p. 555-561 (1999)
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- Abstract
- PURPOSE: To determine whether a new formulated albuterol aerosol could sustain inhibition to bronchoconstriction for approximately one day in guinea pigs challenged with carbachol. METHODS: Large and porous particles, comprising a combination of endogenous or FDA-approved excipients and albuterol sulfate, were prepared by spray drying using a NIRO portable spray drier. The anesthetized animals inhaled 5 mg of large porous or small nonporous particles by forced ventilation via cannulae inserted in the lumen of their exposed tracheae. At regular intervals over a period of 36 hours after drug delivery, airway resistance was determined in response to carbachol challenge dose. RESULTS: Whereas inhalation of small nonporous albuterol particles protected from the carbachol-induced bronchoconstriction for up to 5 hours, inhalation of large porous albuterol particles produced a significant inhibition of carbachol-induced bronchoconstriction for at least 16 hours. CONCLUSIONS: The absence of substantial side effects, verified over a period of 24 hours by evaluating cardio-respiratory parameters as well as pulmonary inflammation, supports the utility of large porous albuterol particles for sustained therapies in asthma and other types of lung disease.
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Ben-Jebria, A., Chen, D., Eskew, M. L., Vanbever, R., Langer, R., & Edwards, D. A. (1999). Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs. Pharmaceutical Research, 16(4), 555-561. https://doi.org/10.1023/A:1018879331061 (Original work published 1999)