Molecular, cellular and tissue mechanisms of endometrial extracellular matrix breakdown leading to abnormal bleeding
(2004)
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Details
- Authors
- Supervisors
- Marbaix, Etienne
- Abstract
- Irregular dysfunctional bleeding of human endometrium is associated to and most likely induced by an untimely focal expression and activation of several MMPs, in particular MMP-1, -2, -3 and -9. Moreover, a decreased expression of TIMP-1 contributes to the degradation of the extracellular matrix in the areas where MMPs are expressed. The herogeneously decreased expression of ER alpha and PRA and B is probably involved in a focal loss of repression of the expression of MMPs, which are induced in the stromal cells by interleukin-1 alpha and/or by other as yet unidentified cytokines. Inflammatory cells, in particular neutrophils with their abundant content of proMMP-8 and -9, are recruited at the same sites and release these zymogens, which, once activated, increase the proteolysis of the extracellular matrix. The menstrual-like degradation of the endometrial extracellular matrix and of the basement membranes underlying the vessels and the surface epithelium will induce a bleeding episode, which probably becomes clinically noticeable when (or because) many superficial areas of the endometrium simultaneously undergo the lytic process.
- Affiliations
Citations
Galant, C. (2004). Molecular, cellular and tissue mechanisms of endometrial extracellular matrix breakdown leading to abnormal bleeding. https://hdl.handle.net/2078.5/129686