Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods.
(2021) Seminars in Arthritis and Rheumatism — Vol. 51, n° 4, p. 940-945 (2021)
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- OBJECTIVE: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. METHODS: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). RESULTS: In exercises 3-4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58-0.65 (WIPE-osteitis), 0.10-0.88 (HIMRISS-osteitis) and for status/change 0.38-0.72/0.52-0.60 (WIPE-synovitis/effusion) and 0.68-0.89/0.78-0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. CONCLUSION: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.
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Wetterslev, M., Lambert, R. G., Maksymowych, W. P., Eshed, I., Pedersen, S. J., Bird, P., Stoenoiu, M., Krabbe, S., Mathew, A. J., Foltz, V., Gandjbakhch, F., Paschke, J., De Marco, G., Marzo-Ortega, H., Carron, P., Poulsen, A. E., Jaremko, J. L., Conaghan, P. G., & Østergaard, M. (2021). Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods. Seminars in Arthritis and Rheumatism, 51(4), 940-945. https://doi.org/10.1016/j.semarthrit.2021.05.006 (Original work published 2021)