Synthesis, Characterization and Invitro Antitumor-activity of Di-normal-butyltin(iv) Derivatives of Some Aromatic Carboxylic-acids, Including Aspirin
(1991) Applied Organometallic Chemistry — Vol. 5, n° 3, p. 195-201 (1991)
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- Eleven di-n-butyltin(IV) derivatives of the type (a) (C4H9)2(XYC6H3COO)2Sn or (b) {[(C4H9)2(XYC6-H3COO)Sn]2O}2 (X, Y = H, 2-OH, compound la; H, 2-OCH3, compounds 2a and 2b; H, 2-OCOCH3, 3a; 2-OH, 3-OCH3, 4a; 2-OH, 3-CH3, 5a; H, 3-OCH3, 6a and 6b; H, 3-N(CH3)2, 7a; H, 2-(CF3), 5-(CF3), 8a and 3-OCH3, 4-OH, 9a) have been prepared and characterized by H-1, C-13 and Sn-119 NMR, Mossbauer and mass spectroscopy. The in vitro antitumour activity of these compounds against MCF-7 human tumour cells was higher than that of cis-platin, but only three compounds, 4a, 8a and 9a, scored better than cis-platin against the WiDr cell line.
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Meriem, A., Willem, R., Biesemans, M., Mahieu, B., Devos, D., Lelieveld, P., & Gielen, M. (1991). Synthesis, Characterization and Invitro Antitumor-activity of Di-normal-butyltin(iv) Derivatives of Some Aromatic Carboxylic-acids, Including Aspirin. Applied Organometallic Chemistry, 5(3), 195-201. https://doi.org/10.1002/aoc.590050309 (Original work published 1991)