Adult onset of multifocal eosinophilic granuloma of bone: a long-term follow-up with evaluation of various treatment options and spontaneous healing

Boutsen, Yves;Esselinckx, Walter;Delos, Monique;Nisolle, Jean-François
(1999) Clinical Rheumatology — Vol. 18, n° 1, p. 69-73 (1999)

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Abstract
We report a case of multifocal-monosystemic Langerhans cell histiocytosis (LCH), formerly usually referred to as eosinophilic granuloma (EG) of bone. The condition developed in a 36-year-old man. A notable infrequent thoracic spine location and two successive distinct costal lesions were observed. Both the first costal site and the vertebral location healed spontaneously; the second costal lesion underwent biopsy resection. The patient's disease course with an 8-year follow-up is discussed with reference to various treatment options, emphasising in selected cases a watchful conservative approach, in view of the widely documented potential for spontaneous healing.
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Boutsen, Y., Esselinckx, W., Delos, M., & Nisolle, J.-F. (1999). Adult onset of multifocal eosinophilic granuloma of bone: a long-term follow-up with evaluation of various treatment options and spontaneous healing. Clinical Rheumatology, 18(1), 69-73. https://doi.org/10.1007/s100670050058 (Original work published 1999)