Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

Nagant, Carole; Barbezange, Cyril; Dedeken, Laurence; Besse-Hammer, Tatiana; Mahadeb, Bhavna; Efira, André; Ferster, Alice; Corazza, Francis; Krammer, Florian; Thomas, Isabelle

doi:10.1371/journal.pone.0223991

Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

Nagant, Carole

;

Barbezange, Cyril

;

Dedeken, Laurence

;

Besse-Hammer, Tatiana

;

Thomas, Isabelle

;et.al.

(2019) PLOS ONE — Vol. 14, n° 10, p. e0223991 (2019)

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Authors

Nagant, Carole
Author
Barbezange, Cyril
Author
Dedeken, Laurence
Author
Besse-Hammer, Tatiana
Author
Thomas, IsabelleUCLouvain
Author

Abstract

Patients suffering from Sickle Cell Disease (SCD) are at increased risk for complications due to influenza virus. Annual influenza vaccination is strongly recommended but few clinical studies have assessed its immunogenicity in individuals with SCD. The aim of this study was to explore the biological efficacy of annual influenza vaccination in SCD patients by characterizing both their humoral and cell-mediated immunity against influenza antigen. We also aimed to investigate these immunological responses among SCD individuals according to their treatment (hydroxyurea (HU), chronic blood transfusions (CT), both HU and CT or none of them).

Affiliations

UCLouvainSSH/LIDAM/CORE - Center for operations research and econometrics

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Nagant, C., Barbezange, C., Dedeken, L., Besse-Hammer, T., Mahadeb, B., Efira, A., Ferster, A., Corazza, F., Krammer, F., & Thomas, I. (2019). Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease. PLOS ONE, 14(10), e0223991. https://doi.org/10.1371/journal.pone.0223991 (Original work published 2019)