Radiostability of pharmaceuticals under different irradiation conditions

Crucq, Anne-Sophie;Deridder, Véronique;Tilquin, Bernard
(2005) Radiation Physics and Chemistry — Vol. 72, n° 2-3, p. 355-361 (2005)

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Authors
  • Crucq, Anne-Sophie
    Author
  • Deridder, VéroniqueUCLouvain
    Author
  • Tilquin, BernardUCLouvain
    Author
Abstract
In this paper, the products studied are cefazolin, glucagon and dobutamine HCl. The radioresistance of pharmaceuticals may depend on the conditions of irradiation. The best is to irradiate the drugs in solid state and the chemical transformations can be reduced also by lowering the temperature of the liquid. In solid state. the dose rate has no influence on the decomposition for the selected molecules and it should be noted that drug excipients selected for bioavailability reasons are not always radioprotectors. These results are important from a technical point of view in pharmaceutical industry. (C) 2004 Elsevier Ltd. All rights reserved.
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Crucq, A.-S., Deridder, V., & Tilquin, B. (2005). Radiostability of pharmaceuticals under different irradiation conditions. Radiation Physics and Chemistry, 72(2-3), 355-361. https://doi.org/10.1016/j.radphyschem.2004.02.006 (Original work published 2005)