Steady-state evoked potentials to study nociception and vibrotaction in humans
(2014)
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Details
- Authors
- Supervisors
- Mouraux, André
- Abstract
- During the past 30 years, researchers have extensively used electrophysiological and functional neuroimaging methods to investigate the neural basis of pain perception and shown that nociceptive stimuli commonly elicit activity within a wide array of subcortical and cortical brain structures. Nevertheless, there is overwhelming evidence that these brain areas are also involved in other sensory, emotional, cognitive, motor and autonomic functions, and that the largest part of the brain responses to transient nociceptive stimuli could reflect cortical activity unspecific for nociception, such as multimodal cognitive processes involved in the detection and the orientation of attention towards the occurrence of a transient, salient sensory event. One of the major goals of this dissertation was to develop new methods to explore non-invasively the cortical activity related to nociception in human in order to progress in our understanding of how nociception is processed in the human brain. More precisely, we developed, with EEG, the approach of nociceptive steady-state evoked potentials (SS-EP). In other sensory modalities, SS-EPs have been shown to reflect, at least partly , activity originating from primary sensory cortices. The recording of nociceptive SS-EPs could thus constitute a promising approach to study the cortical processes specifically involved in nociception. Non-invasive EEG techniques are also of particular interest to investigate how neural activities belonging to distinct sensory modalities can interact or be integrated at cortical level and in particular how attentional processes are involved in these interactions. In everyday life, while we are sometimes exposed to external stimuli activating a single sensory modality, most ecological stimuli are multimodal. Another major goal of this dissertation was to investigate how SS-EPs can be used to characterize interaction and integration between nociceptive and non-nociceptive somatosensory inputs, or between other senses, at the cortical level.
- Affiliations
Citations
Colon, E. (2014). Steady-state evoked potentials to study nociception and vibrotaction in humans. https://hdl.handle.net/2078.5/196162