Fed-batch biological reactors are good candidates for the application of adaptive nonlinear techniques because they involve kinetic parameters that are highly uncertain and slowly time-varying. In this paper, the issue is illustrated and discussed with the aid of an industrial application: the ethanol regulation in yeast production processes.
Chen, LB., Bastin, G., & Vanbreusegem, V. (1995). A Case-study of Adaptive Nonlinear Regulation of Fed-batch Biological Reactors. Automatica, 31(1), 55-65. https://doi.org/10.1016/0005-1098(94)00068-T (Original work published 1995)