Consensus nomenclature for CD8 T cell phenotypes in cancer
(2015) OncoImmunology — (2015)
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- Authors
Van den Eynde, Benoît 
- Abstract
- Whereas preclinical investigations and clinical studies have established that CD8 T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8 T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8 T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8 T cell immunity, leading to the emergence of dysfunctional CD8 T cells. The existence of different types of CD8 T cells in cancer calls for a more precise definition of the CD8 T cell immune phenotypes in cancer and the abandonment of the generic terms “pro-tumor” and “anti-tumor”. Based on recent studies investigating the functions of CD8 T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8 T cells in cancer.
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Citations
Apetoh, L., Smyth, M., Drake, C., Abastado, J.-P., Apte, R., Ayyoub, M., Blay, J.-Y., Bonneville, M., Butterfield, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Chen, L., Colombo, M., Comin-Anduix, B., Coukos, G., Dhodapkar, M., Dranoff, G., et al. (2015). Consensus nomenclature for CD8 T cell phenotypes in cancer. OncoImmunology. Accepted/in-press. https://hdl.handle.net/2078.5/50467 (Original work published 2015)