The authors report on the case of a 5,8 year-old girl whose father died of medullary thyroid carcinoma. When she was 4,5 year-old, her physical examination was normal but plasma calcitonin and katacalcin (PDN-21) levels were abnormally high in response to pentagastrin infusion. Total thyroidectomy was performed and immunohistochemical staining showed confluent C-cell hyperplasia. No recurrence occurred in this patient over four years on follow-up.
Brichard, B., Maes, M., Rahier, J., Henrot, B., Jonard, C., & Malvaux, P. (1993). [Total Thyroidectomy Revealing C-cell Hyperplasia in a Kindred Child With Familial Medullary-thyroid Carcinoma]. Pediatrie, 48(5), 373-376. https://hdl.handle.net/2078.5/71122 (Original work published 1993)