Enabling Enantiopurity: Combining Racemization and Dual-Drug Co-crystal Resolution

Harmsen, Bram;Leyssens, Tom
(2018) Crystal Growth & Design — Vol. 18, n° 6, p. 3654-3660 (2018)

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Abstract
A new process methodology to obtain enantiopure (S)-Ibuprofen has been designed. Starting from racemic Ibuprofen, co-crystallization with Levetiracetam is used as a resolution tool to obtain only the target enantiomer,(S)-Ibuprofen, in the solid state. The resulting mother liquor, enriched in (R)-Ibuprofen, is recovered and submitted to a racemization cycle, after which another co-crystallization step is introduced. Levetiracetam can be recovered from the co-crystal phase and reused, resulting in an economical use of the resolution agent. Overall, a novel approach to transform a racemic compound into enantiopure material has been developed.
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Harmsen, B., & Leyssens, T. (2018). Enabling Enantiopurity: Combining Racemization and Dual-Drug Co-crystal Resolution. Crystal Growth & Design, 18(6), 3654-3660. https://hdl.handle.net/2078.5/55203 (Original work published 2018)