Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores

Kassehin, Comlan Urbain;Gbaguidi, Fernand A.;McCurdy, Christopher R.;Poupaert, Jacques
(2015) Journal of Chemical and Pharmaceutical Research — Vol. 7, n° 7, p. 48-55 (2015)

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Authors
  • Kassehin, Comlan UrbainUCLouvain
    Author
  • Gbaguidi, Fernand A.UCLouvain
    Author
  • McCurdy, Christopher R.
    Author
  • Poupaert, JacquesUCLouvain
    Author
Abstract
African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology. In this context, in order to create novel anti-protozoa prototype containing both a trypanocidal thiosemicarbazide moiety and an immuno-potentiating thalidomide-like, a hybrid structure was designed on the basis of a convergent synthesis process, synthesized and assayed for its potential trypanocidal activity. Initial biological results are very promising. The structure of the target compound was ascertained on the basis of 13C-NMR, IR spectroscopy and semi-empirical AM1/PM3 quantum-mechanical calculations.
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Kassehin, C. U., Gbaguidi, F. A., McCurdy, C. R., & Poupaert, J. (2015). Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores. Journal of Chemical and Pharmaceutical Research, 7(7), 48-55. https://hdl.handle.net/2078.5/38139 (Original work published 2015)