On the role of dopamine replacement therapy in decision-making, working memory, and reward in Parkinson's disease: does the therapy-dose matter?

Torta, Diana;Castelli, Lorys;Zibetti, Maurizio;Lopiano, Leonardo;Geminiani, Giuliano
(2009) Brain and Cognition — Vol. 71, n° 2, p. 84-91 (2009)

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Authors
  • Torta, Dianaorcid-logoUCLouvain
    Author
  • Castelli, Lorys
    Author
  • Zibetti, Maurizio
    Author
  • Lopiano, Leonardo
    Author
  • Geminiani, Giuliano
    Author
Abstract
Dopaminergic therapy proved to ameliorate motor deficits in Parkinson's disease but its effects on behavior and cognition vary according to factors that include, among others, the evolution of the disease and the nature of the task that is tested. This study addressed the question of whether, in moderate to advanced Parkinson's disease (PD) with motor fluctuations, changes in decision-making and sensitivity to reward occur and to what extent dopaminergic therapy plays a role.
Affiliations
  • University of TurinDepartment of Psychology

Citations

Torta, D., Castelli, L., Zibetti, M., Lopiano, L., & Geminiani, G. (2009). On the role of dopamine replacement therapy in decision-making, working memory, and reward in Parkinson’s disease: does the therapy-dose matter? Brain and Cognition, 71(2), 84-91. https://doi.org/10.1016/j.bandc.2009.04.003 (Original work published 2009)