Impact of first-line chemotherapy prior to ovarian tissue cryopreservation on primordial follicle activation and survival in pre-pubertal and young adult patients.
How chemotherapeutic regimen administered prior to ovarian tissue cryopreservation affect the signaling pathways regulating the ovarian reserve and follicular survival in pre-pubertal and adult patients? 3. Summary answer (25): Chemotherapy induces key signaling processes of follicle activation and increases apoptosis in quiescent follicle. However, damages were different according to the age of the patient.
Melody Devos, Paula Diaz Vidal, Ellen Anckaert, Dolmans, M.-M., & Isabelle Demeestere. (2021). Impact of first-line chemotherapy prior to ovarian tissue cryopreservation on primordial follicle activation and survival in pre-pubertal and young adult patients. ESHRE virtual Meeting 2021. https://hdl.handle.net/2078.5/109094