A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.
(1995) Proceedings of the National Academy of Sciences of the United States of America — Vol. 92, n° 17, p. 7976-7980 (1995)
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- Abstract
- We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions.
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Citations
Coulie, P., Lehmann, F., Lethé, B., Lurquin, C., Andrawiss, M., Boon, T., & Herman, J. (1995). A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proceedings of the National Academy of Sciences of the United States of America, 92(17), 7976-7980. https://doi.org/10.1073/pnas.92.17.7976 (Original work published 1995)