A pragmatic trial of acamprosate in the treatment of alcohol dependence in primary care.
(2004) Alcohol and Alcoholism — Vol. 39 (2004)
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- Authors
Lehert, Philippe 
- Abstract
- (en) To assess the effectiveness of pharmacotherapy with acamprosate in alcohol-dependent patients treated in a naturalistic setting in primary care in France. 422 patients were included. At the end of the study, patients randomized to the acamprosate group had significantly better outcomes in terms of total ARPQ score, change from baseline (–2.61 vs –3.44) and number of subjects with no alcohol-related problem. On average, patients treated with acamprosate had one less alcohol-related problem than did the controls. The number needed to treat in order to save one additional patient from alcohol-related problems compared to standard care was 7.14. Statistically significant differences in favour of the acamprosate group were observed for all secondary efficacy outcome measures including quality of life. Adjunctive therapy with acamprosate in primary care is associated with significantly better functional outcome. Pragmatic trials in alcohol dependence are both feasible and informative.
- Affiliations
Louvain School of Management
Citations
Kiritzé-Topor, P., Rozenzweig, C., Lehert, P., Paille, F., Comte, S., & Huas, D. (2004). A pragmatic trial of acamprosate in the treatment of alcohol dependence in primary care. Alcohol and Alcoholism, 39. https://doi.org/10.1093/alcalc/agh088 (Original work published 2004)