An eight-year-old boy with Fanconi's anaemia received a bone marrow transplantation from an unrelated donor. Sustained engraftment was achieved, but he developed major complications including acute grade III graft-versus-host disease, autoimmune haemolytic anaemia with positive Coombs' test and free antibodies against Rhesus group, and a virus-associated haemophagocytic syndrome; this latter complication was successfully treated with acyclovir. Sixteen months after transplantation he has full haematopoietic reconstitution, but with persisting mild autoimmune haemolysis.
Sokal, E., Michel, M., Ninane, J., Latinne, D., De Bruyère, M., & Cornu, G. (1987). Bone marrow transplantation from an unrelated donor for Fanconi’s anaemia: two unusual complications. Bone Marrow Transplantation, 2(1), 99-102. https://hdl.handle.net/2078.5/53292 (Original work published 1987)