Activation des gènes cancer-germline dans les tumeurs : conséquences épigénétiques
(2024)
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- Authors
- Supervisors
- De Smet, Charles
- Abstract
- The initiation and development of tumors are partly attributed to the accumulation of epigenetic alterations within chromatin. DNA methylation profiles are significantly altered in cancer cells by mechanisms that lead to both gains (hypermethylation) and losses (hypomethylation) of DNA methylation in different regions of the genome. Hypermethylation primarily affects tumor suppressor genes, resulting in an irreversible loss of their functions, while hypomethylation often leads to the ectopic activation of germline-specific genes, known as cancer-germline genes. In this work, we identified a novel mechanism linking hypomethylation to hypermethylation through the activation and overlapping of a cancer-germline-like transcript. The consequences of this hypermethylation process via overlapping transcription in neoplastic development were evaluated. These observations provide a promising avenue for the development of diagnostic tools to identify genes susceptible to becoming hypermethylated, thereby offering a valuable advantage in combating tumor progression.
- Affiliations
Citations
Fain, J. (2024). Activation des gènes cancer-germline dans les tumeurs : conséquences épigénétiques . https://hdl.handle.net/2078.5/236099