Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study
(2003) Contact Dermatitis : environmental and occupational dermatitis — Vol. 48, n° 3, p. 158-161 (2003)
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- Abstract
- Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
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Ducombs, G., Lepoittevin, J., Berl, V., Andersen, KE., Brandao, FM., Bruynzeel, DP., Bruze, M., Camarasa, JG., Frosch, PJ., Goossens, A., Lachapelle, J.-M., Lahti, A., Le Coz, C., Maibach, HI., Menne, T., Seidenari, S., Shaw, S., Tosti, A., & Wilkinson, JD. (2003). Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study. Contact Dermatitis : environmental and occupational dermatitis, 48(3), 158-161. https://doi.org/10.1034/j.1600-0536.2003.00077.x (Original work published 2003)