Enhancing the biological integration of massive bone allograft by a tissue engineering approach : from perfusion-decellularization to recellularization
(2024)
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RobinEvrard-Thesis-Final.pdf
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Details
- Authors
- Supervisors
- Schubert, Thomas
- Abstract
- In reconstructive orthopedic surgery, massive bone allografts are essential tool in our therapeutic arsenal for compensating significant bone tissue loss. However, they are associated with a high rate of postoperative complications, which can compromise patient quality of life and, in some cases, prognosis. This doctoral thesis proposes a novel treatment method aimed at enhancing the osseous integration of these allografts. By considering bone as a complete organ, we leverage its intrinsic vascular network to maximize biological capabilities. Through extensive in vitro studies, preclinical tests on porcine models, and cell therapy-based recellularization trials, this work seeks to comprehensively characterize this new generation of bone allografts and their potential future benefits.
- Affiliations
Citations
Evrard, R. (2024). Enhancing the biological integration of massive bone allograft by a tissue engineering approach : from perfusion-decellularization to recellularization. https://hdl.handle.net/2078.5/235072