Dual association of a TRKA polymorphism with schizophrenia
(2011) Psychiatric Genetics — Vol. 21, n° 3, p. 125-131 (2011)
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- Abstract
- Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Citations
Van Schijndel, J. E., Van Zweeden, M., Van Loo, K. M. J., Djurovic, S., Andreassen, O. A., Hansen, T., Werge, T., Nyegaard, M., Sørensen, K. M., Nordentoft, M., Mortensen, P. B., Mors, O., Børglum, A. D., Del-Favero, J., Norrback, K.-F., Adolfsson, R., Hert, M. D., Claes, S., Cichon, S., et al. (2011). Dual association of a TRKA polymorphism with schizophrenia. Psychiatric Genetics, 21(3), 125-131. https://doi.org/10.1097/YPG.0b013e3283437194 (Original work published 2011)